On the one hand, this is an example of a phenotypic cover-up mediated by molecular chaperones.
It would be of interest, therefore, to investigate whether the effect on neuronal survival and reduced vacuolation shown here is mediated by metabolic changes induced by a phenotypic shift of astrocytes.
In summary, our results show that lipid accumulation in MCF-7 cells is a phenotypic cell fate decision that is mediated by the PI3K signalling pathway through a combined stimulation of endogenous lipid synthesis and the mTORC signalling pathway.
Serum response factor (SRF) is a transcription factor known to mediate phenotypic plasticity in smooth muscle cells (SMCs).
A careful characterization of two cage types, including a comparison of the auditory and temperature environments, coupled with a demonstration that naris occlusion abolishes the neuroanatomical changes, lead us to conclude that a likely important factor mediating the phenotypic changes we find is the olfactory environment of the two cages.
Try to mediate a resolution.
These results again suggest that Klf5 plays an important role in mediating VSMC phenotypic switching into osteogenic cells and calcification.
Association studies using candidate genes and genome-wide approaches have provided clues to loci that might mediate phenotypic variation but with 2 notable exceptions a detailed understanding of the relationship between putative modifying genes and the phenotypes of sickle cell disease and β thalassemia has not been achieved.
It is not immediately obvious if any of the other genes with annotated functions affected by inactivating changes would mediate phenotypic changes in the cluster SMI-049 strains although dhaA (encoding a haloalkane dehalogenase) has been shown to be upregulated upon in vitro infection of a macrophage cell line [78].
At present, there is no clear evidence of a general, cross-species link between testosterone, genetically mediated immunity, phenotypic health and trait size, from which patterns among humans can straightforwardly be inferred.
