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All these drugs inhibit cyclo-oxygenase (COX) which catalyses the conversion of arachidonic acid to prostaglandin H2, a precursor of the prostanoids which are important mediators of inflammatory reactions, but which also mediate a host of other functions.
Mr. Annan was still venerated throughout the rest of the world, and after retiring from the United Nations in 2006 he soon took on a role in the mold of former South African president Nelson Mandela, as a wise, noble elder trying to mediate a host of conflicts in his native Africa.
Though integrin cytoplasmic tails are typically short, they mediate a host of critical interactions.
Emerging data demonstrate that SP-A and SP-D also mediate a host defence function [ 16].
Saitoh, T. et al. Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
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Endogenously generated nitric oxide (NO) mediates a host of important physiological functions, playing roles in the vascular, immunological, and neurological systems.
Therefore, a specific AnkA could mediate a distinct host tropism of a particular A. phagocytophilum isolate and be involved in host adapation.
We consider that the common finding in reduction of microgliosis could involve drug effects to reduce microglial chemotactic responses mediated by a host of chemokines and inhibition of subsequent cell activation mediated by a host of receptors (noted above).
As we can see from literature, HSP70 that is released from tumour cells undergoing chemotherapy may mediate a danger signal to the host's immune system [ 13, 14].
All the vaccines at present are mostly based on B-cell immunity, whereas, in this case, a vaccine based on T-cell epitope was inspired by the fact that the host can mediate a strong immune response by CD8+ T cell to infected cell.
Catecholamines secretion from fish chromaffin cells is mediated by a host of cholinergic and non-cholinergic pathways that warrant sufficient dynamics in the secretion process to permit harmonized responses to a wide array of stressors36.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com