Sentence examples for mediate a critical from inspiring English sources

Igs mediate a critical part of the adaptive immune response.

The PfRH5 protein is now known to mediate a critical nonredundant interaction with the human RBC surface protein basigin during invasion (Crosnier et al., 2011).

This regulatory element is known to bind multiple erythroid and ubiquitous transcription factors and to mediate a critical enhancer function required for developmentally regulated globin gene expression.

The human β-secretase enzyme, BACE1, mediates a critical step in the production of Aβ40 and Aβ42 peptides which are responsible for the severe neuronal cell death and insoluble amyloid plaques of Alzheimer's disease (AD).

Cyclooxygenase (COX) mediates a critical metabolic step in prostanoid biosynthesis.

So far, we demonstrated that Delg mediates a critical link between nutrients and mitochondria.

This gene mediates a critical rate-limiting step in physiological angiogenesis and plays a key role in tumor progression and angiogenesis and its expression by primary tumor promotes lymphangiogenesis and facilitates metastasis to sentinel lymph nodes [ 62].

These alternative fusions suggest that EWS mediates a critical change in ETS family transcription factors that allows them to function aberrantly and promote tumor development, possibly through incorrect regulation of target gene expression.

In lethal polymicrobial sepsis, toll-like receptor 4 (TLR-4) mediates a critical role in impeding the migration of neutrophils to infectious foci, thereby favoring increased bacteremia and ultimately leading to mortality.

The adhesion process mediated is a critical step of a wide range of immunological activities, including cytolysis of target cells, cross-interaction and cross-stimulation between lymphocytes, phagocytosis of complement-coated targets, neutrophils clearance from inflamed tissue, and the regulation of leukocyte traffic between the bloodstream and tissues [ 6- 9].

Data were presented demonstrating that interaction of this kinase with the very C-terminus of the LMP1 signaling domain is mediated by TRAF6, a critical signaling mediator of LMP1 and cellular members of the TNF-receptor and TLR families.