XAC, NECA, and adenosine mediated a concentration-dependent inhibition in the binding and, as such, the plasma membrane fluorescence of 30 nM ABA-X-BY630 (Fig. 6 A C ).
At CHO-A3 cells, the nonselective adenosine receptor antagonist, XAC, the nonselective adenosine receptor agonist, NECA, and the endogenous agonist, adenosine, mediated a concentration-dependent increase in the dissociation rate of ABA-X-BY630 (Figs. 3 and 4 A C ).
We showed that overexpression of wild-type ESR1 potently (about 3.6 times control vector) stimulated ESR1 mediated transcription in a concentration-dependent fashion (Fig. 6A), while overexpression of Δ7 ESR1 failed to elicit a transcriptional response at any dose.
Glyceollins were shown to reverse MRP2-mediated CDF transport asymmetry in a concentration-dependent manner, with activity similar to the MRP2 inhibitor, MK-571.
Using the whole cell patch clamp technique, CGX-1007 and CI-1041 were found to block CA1 pyramidal cell, NMDA receptor-mediated excitatory postsynaptic currents (N-EPSCs) in a concentration-dependent manner in hippocampal slices from P4 P6 animals.
Both cell types lack MHC-II expression, primarily mediate their immunosuppressive effects via prostaglandin E2, and displayed a concentration-dependent immunosuppressive effect when added to MLRs [ 14, 26].
Such immune complexes also increased proliferative activity of cultured human monocytes, and this effect was mediated by cross-linking of Fc gamma receptor I; a concentration-dependent production of monocyte colony-stimulating factor was observed.
C5a was found to mediate Th1 (as per IFN- γ production) and Treg cell differentiation in a concentration-dependent, bell-shaped fashion such that high C5a levels decreased Th1 and increased Treg differentiation.
GKA (RO28-1675) caused a concentration-dependent inhibition of 1-10 μM in glucose mediated Smad2C phosphorylation.
In isolated mesenteric microvessels from control rats, two hours incubation with IL-1β (1 to 10 ng/mL) produced a concentration-dependent impairment of endothelium-dependent relaxations, which were mediated by enhanced NADPH oxidase activity via IL-1 receptors.
