Sentence examples for mediate a broad from inspiring English sources

Natriuretic peptides (NPs) are a family of structurally related hormone/paracrine factors (ANP, BNP and CNP), which mediate a broad array of physiological effects by interacting with specific guanylyl cyclase receptors (NPR) and have promising therapeutic and clinical applications.

The assembly of eukaryotic ribosomes is a highly complex multi-step process that requires more than 200 ribosome biogenesis factors, which mediate a broad spectrum of maturation reactions.

They mediate a broad spectrum of immunomodulatory activities both intracellular and extracellular, including induction of apoptosis, negative regulation of T-cell response, cell adhesion, and pre-mRNA splicing [ 54].

IFITs mediate a broad range of protein protein interactions; in particular, the tetratricopeptide repeat motif is critical for modulating protein translational initiation and transport, cell proliferation and migration, virus replication, and antiviral signaling.

The alternating expression of these regions, previously observed in S.erythraea using microarrays [ 6], is able to mediate a broad coordinated suite of genetic changes, representing a broad architectural mechanism by which a cell can rapidly modulate large changes in the transcriptome in response to environmental cues [ 31].

Transmembrane calnexins and soluble calreticulins support trafficking, sorting and maturation of glycoproteins whereas lectins localized in the plasma membrane or released into the extracellular matrix and body fluids mediate a broad range of processes including cell adhesion, cell signalling, pathogen recognition and endocytosis.

The Forkhead Box (Fox) gene class of transcription factors is responsible for mediating a broad range of cellular activity.

CD27 and CD 40 are essential in mediating a broad variety of immune and inflammatory responses [ 28], consistent with their increased gene expression in OA patients rather than in OP patients.

Lysophosphatidic acid (LPA; 1- or 2-acyl sn-glycero-3-phosphate), the simplest glycerophospholipid, mediates a broad range of cellular responses including smooth muscle cell contraction, platelet aggregation, neurite retraction/cell rounding, regulation of cell proliferation, protection from apoptosis, modulation of chemotaxis and transcellular migration [ 1- 3].

Suppressing OsDR10 mediated a broad-spectrum resistance to Xoo accompanying the activation of the SA-dependent pathway and suppression of the jasmonic acid (JA -dependent pathway, suggesting that OsDR10 is a negative regulator of rice disease resistance.

It would be useful to apply reverse-correlation methods such as ours to examine transitions between this rich set of behavioral states to identify how specific neurons mediate a broader range of behavioral decisions than navigation up or down stimulus gradients.