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Since the only difference between these two cell lines are COX-2 and that could mediate a balance between apoptosis and cell survival, we analysed the expression of COX-2 along with its transcription factor NFκB. Decreased expression of cox-2 transcripts in 75 µM plumbagin treated HT29 indicates that COX-2 plays a crucial role in plumbagin induced apoptosis.
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In general, he sees markets not as mediating a balance between supply and demand but as favoring one constituency over another.
From these findings we conclude that the transcriptional MBD2 repressor and ERα transactivator co-participate to the regulation of pS2 expression by mediating a balance between repressive histone H3 lysine 9 trimethylation and active histone H3 acetylation marks at pS2 promoter.
mTOR through various downstream effectors mediates a balance between cell growth and protein degradation.
The critical gene, well known for its role in suppressing tumors, seems to mediate a profound balance between life and death.
Thus, SIRT1 appears to mediate a delicate balance between its anti-growth and pro-growth properties.
Histone acetylation is mediated by a balance between histone acetyltransferases (HATs) and the three classes of histone deacetylases (HDACs): Class 1 (HDAclass8), class 2 (HDand-7,9-11), and class 3 (Sirt1-7).
DOI: http://dx.doi.org/10.7554/eLife.06462.019 We further propose that chromosome movement on acentrosomal spindles is mediated through a balance of plus- and minus-end directed forces operating on chromosomes.
As their name suggests, NK cells have an intrinsic ability to spontaneously lyse virally infected and cancerous cells, a function that is normally mediated by a balance of activating receptors (e.g., NKG2D) and inhibitory receptors (killer immunoglobulin-like receptors (KIR), NKG2A) [ 2].
Therefore, the edited let-7a-5C may play a role for mediating a proper balance between MMP-2 level and embryo invasion for the successful pregnancy through Smad7.
Thus, Baicalin appeared to play a dual role in T-cell differentiation by mediating a reciprocal balance of Foxp3 and RORγt.
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Justyna Jupowicz-Kozak
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