Sentence examples for mediate a β from inspiring English sources

Insulin can mediate A β degradation by activating insulin-degrading enzyme (IDE) [ 163].

It has been recently reported that LRP-1 and HSPGs mediate A β internalization in a seemingly cooperative manner, in which HSPG is more important for A β binding to cell surface than LRP-1 [ 88].

These data suggest that GSK-3 may mediate the A β-AGE-induced exacerbation of neural impairments.

The h2i is folded differently than in other AAA+ proteins to mediate a β-sheet interface with the ps1β of a subunit in the other octamer.

Furthermore, we demonstrated that RanBP9 induces neurodegeneration and synaptic loss associated with spatial memory deficits and that RanBP9 is essential to mediate A β-induced neurotoxicity.

Here, we show that NR2A- and NR2B-subunit containing NMDARs differentially mediate A β-induced tau phosphorylation, cell death and dendritic spine loss.

To determine if astrocytes mediate A β-induced tau phosphorylation in our model system, cell lysates from A β-treated mixed and neuronal cultures were assessed by western blotting.

Among several proposed surface A β oligomer receptors such as PrPc (Prion protein (cellular))/mGluR5 (metabotropic glutamate receptor 5) and paired immunoglobin-like receptor-B (Pir-B), it has been shown that α2/ β1 and αv/ β1-integrins are also required to mediate A β-induced apoptosis and impairment in LTP.

Knowing that A β reduces P-gp expression at the transcription level, we examined which signaling pathway mediated the A β-induced decrease in P-gp expression by using specific inhibitors.

Blocking the A β1 42 RAGE interactions with a neutralizing antibody against RAGE confirmed that RAGE mediates the A β-induced decrease of P-gp expression, as bEnd.3 cell treated with A β1 42 in the presence of anti-RAGE antibody showed attenuation.

The results that were obtained from the murine brain EC line bEnd.3 showed that the RAGE NF- κB signaling pathway mediated the A β-induced decrease in P-gp expression, and that the induction was possible only when ECs did not receive inductive signals or factors from astrocytes that were making contact with ECs.