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Robust regression [ 20] or median-based methods could be employed to reduce the adverse impact of arbitrary assignment of high values, yet still allow inclusion of all the observations in construction of calibration curves.
Other than total cohort median-based separation of patients, we also examined the relation of JMJD6 levels and prognosis by quartile assignment of JMJD6 expression in each subtype independently.
In addition, a median-based wavelet spectrum is introduced.
Median-based normalization methods [43, 65 68] are also widely used.
Our empirical test of higher taxonomic assignments reveals that a tree-based assignment system would successfully assign most queries to a higher taxon at some level.
In addition to tree-based assignment we used criteria based on direct sequence comparison.
A model-based assignment test was performed based on microsatellite data using STRUCTURE 2.0 [ 31].
Central assignment involving an Internet-based assignment system will be performed.
We suggest that model-based assignment tests are one such tool.
All these observations support the phylogeny-based assignment of Latimeria t2r and v1r genes.
The unambiguous NOEs alone yield already an important constraint for structure-based assignment.
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