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The training dataset was segmented by the median MTVwb of 85.6 mL, Kaplan-Meier survival curves (Fig. 2) demonstrate decreased OS among patients with MTVwb greater than or equal to the median, when compared to those patients with MTVwb less than the median (p = 0.021).
While, baseline values of CEC prior to drug exposure showed a trend to lower values (40 ± 41 CEC/ml) in patients with a PFS above the median when compared to patients with a PFS below the median (53 ± 45 CEC/ml), these differences remained insignificant (P = 0.4414) and do not explain treatment outcome as a single pre-dose evaluation.
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Further, because we reported costs by different settings of care and we noted the proportion of total costs for each setting, we chose to report means rather than medians when comparing costs between patients with ADPKD and their matched controls.
Regarding cooperation, which was investigated as a self-report of patients on the VAS score, it was found that the group without bracket failure presented the highest score (median 74.4) when compared to the group with breakage (median 58.00), p ≤ 0.001 (Fig. 1).
Although generally PTEN mRNA expression was rather low in tissues, still there was a statistically significant reduction in expression in cancer tissues (min-max: 0 5.62, median: 0.0085) when compared to the normal tissue (min-max: 0 13.10, median: 0.5, p<0.001).
Moreover, paclitaxel/cisplatin has shown significantly longer median survival when compared to paclitaxel/carboplatin (Rosell et al, 2002).
For each tissue type LSGs have a lower median expression when compared to non-LSGs expressed in the same tissue type.
Another study among Senegalese men with prostate cancer revealed worse tumor stage and median PSA when compared with that of African American men [ 20].
Patients with ECOG PS ≥ 2 had shorter median OS when compared to patients with PS of either 0 or 1 (9.5 vs. 13.3 months, P < 0.001, HR 1.79).
Patients with pan-cytokeratin +/CXCR4+ = 2,500 cells/ml had a significant improvement in median survival when compared with patients with pan-cytokeratin +/CXCR4+ >2,500 cells/ml (not achieved versus 14 weeks).
UFT/LV in first-line metastatic colorectal cancer has shown similar activity in term of response rate and median survival when compared to Mayo clinic bolus 5-FU/LV regimen (Carmichael et al, 2002; Douillard et al, 2002).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com