When comparing the individual mean SUV-measurements in all 20 scans, a median variability (inter-reader CoV) of 3.83% (range 1.80 7.46%) could be observed (see Table 1).
The change in variability (defined as the median variability during the SBT minus the median variability prior to the SBT (that is delta = during to pre), was also computed.
While the median variability for most PCBs was zero, large variability was found in several congeners.
A similar median variability but smaller range compared to our participants was observed in two published studies measuring changes in PCB levels across three and nine years.
Secondary outcomes are number of upright events and mean, maximum, median and variability in length of upright events at 4 months, and all physical behavior variables at 12 months.
Weighted summary statistics that estimate the median and variability in VOC concentrations for the O, S, H, and P samples are presented in Table 2. Six VOCs (benzene, carbon tetrachloride, ethylbenzene, toluene, o-xylene, and m/ p-xylene) were detected in all O samples.
Interestingly, variability in median overall survival were observed between geographical areas, and especially in the chemotherapy only groups, with a median overall survival of 8.6 and 6.8 months in the US and Europe, respectively.
The TLF ratio as their product demonstrated both high sensitivity in median difference but low variability in intra-class quartile range, reflected in the lowest probability of a type I error.
In healthy subjects the median day-to-day variability in MBL concentrations expressed as CV was 6%.
As such, the analyses take into account the inherent variability in median PFS or OS for any given score.
