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At the median the model for women underpredicts WC slightly, and the differences for women are considerably more variable than those for men.
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The mean (median) of the model estimation parameters indicates that the long-term unconditional expectation decreases from the OLS estimates 0.056226 (0.041286) to 0.047367 (0.047367).
By overlaying variations in the above parameters about the median model, the model can encompass the entire spectrum of patients observed in the GenIMS study.
The VPC plots in Figure 3 show that the observed HR and MAP values are well-centered around the predicted median of the model.
The VPC plots in Figure 4 show that the observed plasma glucose and lactate levels are well-centered around the predicted median of the model.
Despite the close agreement regarding variability among these analyses, significant uncertainty remains regarding the appropriate central tendency estimates (e.g., means, medians) for the model parameters and, consequently, for the output of the model.
In the following, we also compute the median model from the K candidate models that is expected to be less influenced by a small number of models showing strong discrepancies.
The relative median error of the model prediction was in general less than 10%.
TFV-DP median Cmax from the model was 38.5 fmol/10 cells, which is bracketed by two reported healthy volunteer studies (38 and 51 fmol/10 cells).
The median regression model provided the best fit to the average dietary total As intake, as indicated by the smaller SE.
It visualizes the median model prediction, the variability between patients and within patients (5th and 95th percentiles), and the uncertainty around the predicted percentiles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com