The estimated standard error obtained for each gene on each array from fitPLM was standardized across arrays so that the median standard error for that gene was 1. NUSE statistics (NUSE median and inter-quartile range IQR) were computed for each array.
PLM computes standard errors of all expression measures, and these are standardized, gene by gene, across arrays, so that the median standard error across arrays is 1.
Basic statistical parameters, such as minimum, maximum, mean, median, standard error (SE), and skewness, were computed along with correlation study.
For finite sample sizes, the mean, median, standard error (se) and 95% confidence intervals of the estimator are calculated based on 500 independent runs.
The median (standard error) RFS and OS were 18 (5) and 68 (34) months, respectively.
aQuartile 1 versus Quartiles 2 to 4. The mean (median, standard error) pretransfusion hemoglobin level was 7.8 (7.7, 0.03) g/dl.
Descriptive statistics (including mean, median, standard error, ranges for continuous data and frequencies and percentages for categorical data) were reported for safety and pharmacokinetic analyses.
Weights applied to the RT quantiles were calculated by estimating the standard error for each of the five quantiles (Maritz and Jarrett, 1978) and then dividing the interpolated median standard error by that of each quantile.
The SE estimates are normalized such that for each probe set, the median standard error across all arrays is equal to 1. Since most genes are not expected to be differentially expressed, boxplots for each array should be centered around 1. Samples with a median GNUSE of greater than 1.25 were flagged for downstream analysis.
There was clear interindividual variability, which is a well known phenomenon in patients with various arthritides including PsA. 4 36 However, on the group level there was a marked decrease in CD3-positive T cells (median (standard error (SE)) of the median: 212 (230) cells/mm) in the adalimumab group (fig 2), whereas in the placebo group there was an increase (36 (33) cells/mm).
