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Median (range) values for CTX clearance, D-CTX clearance and volume of distribution were respectively 0.97 (0.3 7.1) L h−1, 3.2 (0.6–16.3) L h−1, and 3.3 (0.85–20) L. Body weight and post natal age had significant impact on pharmacokinetic.
Median (range) values for Piperacillin clearance and volume of distribution were respectively 3 (0.71–10) L h−1 and 3.8 (0.72–25.8) L. Body weight (allometric relationship), estimated creatinine clearance and PELOD-2 severity score were the covariates explaining the estimated between subject variability.
Results are expressed as occurrences or median (range) values.
Results are expressed as median (range) values.
Continuous variables are given as median (range) values and categorical data as number.
Data are presented as median (range) values or as numbers and proportions.
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Continuous variables were summarized using the mean or median (range) value depending on distribution of data and frequency tables were used to summarize categorical variables.
Data is presented as median (range); P values of less than 0.05 were deemed significant.
Data were presented as median (range); P values were calculated with rank sum test of chromium concentration in erythrocytes.
Median (interquartile range) values are presented.
Median and range values are given for all variable data.
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