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ARS in African children with severe malaria, the median (range) estimates of DHA Cmax, AUC, and t1/2were 547 ng/ml (284 890), 890 h × ng/ml (297 2,510), and 0.427 h (0.145 1.18), respectively, lower than those derived from our pooled PK model for DHA after i.v. ARS.
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Results: We included 50 children with a median (range) post natal age of 27.2 (1.1–222.9) months, median (range) body weight of 11.9 (2.7 50) kg, median (range) PELOD-2 score of 4 (0–16) and median (range) estimated creatinine clearance of 142 (29–675) mL.min-1.m-2.
In these patients, median (interquartile range) estimated glomerular filtration rate significantly decreased from 83.3 mL/min (26.8) before surgery to 60.4 mL/min (32.4) after surgery as assessed by Wilcoxon signed-rank test (P = 0.002).
When these nations were divided into three groups, the median (range) HIV prevalence estimates remained constant at 0.7% (0.05 – 33.7%) and 0.75% (0.05% – 33.4%) for the lower and middle mean governance groups respectively despite improvements in other health and economic indices.
The median (range) difference between the maximum estimate and survival (i.e. maximum estimate-survival) was 29 days (-360 to 572).
The median of this range estimate coincides with the closure of the Tethys Sea c. 18-20 Myr in the Early Miocene, which has been suggested as an alternative hypothesis explaining the distributions of other, albeit terrestrial, taxa [e.g. proboscideans, [ 54]].
We evaluated the lifetime number of sexual partners by estimating the median, range and interquartile bounds (IQB).
Using the results of slide reading from the first microscopist, we determined that the estimated overall median (range) time (hours) to 50% parasitemia and the clearance rate of parasites was 5.1 (0.6–17.8) and 0.16 (0.09–0.26), respectively (Table 2 ).
If the original data were not provided by the authors, the mean and standard deviations were extracted from graphical representation using Ycasd [24] or estimated from the median, range, and sample size [25].
a: mean ± SD, b: median (range), c: Ranges of population energy intake goal as % of total energy, *: estimated energy requirement.
The estimated pharmacokinetic parameters were summarized as mean or median (95% confidence interval (95% CI)) or median (range).
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