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Unlike the genomic distances and genome halving, which can all be calculated in linear time, the genome median problem, based either on d or d B, is NP-hard (Bryant, 1998; Caprara, 2003; Pe'er and Shamir, 1998).
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The numerical method for the solution of this problem, based on the relocation of the boundary condition to the median surface is developed.
PBL: problem based learning.
Not all CBL is problem based, however.
This problem includes the classical p-hub median problem as a special case.
This special case is called median problem in some literatures.
The current implementation of these direct optimization methods are all based on solving the median problems and achieve more accurate results than the maximum likelihood method.
Median Window based methods.
A suitable practical robust solution is the median estimator based on absolute median deviations, named median of absolute median deviations (MAD) estimator [21 23].
This paper provides time definite models for multiple allocation p-hub median problems and hub arc location problems.
That ratio was 23.1 at year-end, compared with a median of 17.8, based on data back to 1950.
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