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The high median percentage decrease from baseline in average weekly rate of drop seizures (85 91%) was maintained through Year 5 (Fig. 2).
The median percentage decrease in total seizures was also maintained, with an 85% reduction from baseline in those patients who had reached Year 5 (Fig. 2).
Prespecified subgroup analyses indicated that, in general, those with the highest baseline values had a greater median percentage decrease (<20 nmol BCE/mmol creatinine, −5 %; 20 50 nmol BCE/mmol creatinine, −28 %; >50 nmol BCE/mmol creatinine, −58 %).
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The median percentage of decrease in the plasma VEGF concentration was 18.3% (range, 7%-41.7%).
The mean percentage decrease in SUVmax was 69% for patients that remained free of disease at a median follow-up of 42 months; the SUVmax decreased by only 37% in patients who eventually developed recurrence[ 20 ].
Median percentage cervical length decrease was 18% (range -14.7 – 56.9).
After three cycles of therapy, we observed decreased median percentage 0.04% ±0.56.
Comparing patients in the subgroup that developed ESRD (n = 40) with those who did not (n = 50), second biopsy specimens from those reaching ESRD showed a higher median index of chronic damage (66.5% vs 29.0%) and decreased median percentage of normal glomeruli (6.0% vs 20.0%).
For continuous variables, data were dichotomized based on an upper limit of normal values (phosphate, potassium, BUN) or low limit (calcium); and median values of the anion gap, hematocrit, percentage decrease in hematocrit, WBC, and CK.
Minnesota clinicians also perceived a decrease in the percentage of patients who requested antimicrobial agents, but the difference was not significant (p = 0.152); the median percentage of Minnesota patients requesting antimicrobial agents decreased from 40% in 1999 to 30% in 2002.
Median total body fat percentage decreased significantly upon weight loss (median change -53%, range -16 to -78%, P < 0.001).
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