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This approach proceeds by first computing the median observed skill of workers employed in each occupation, and then, it defines minimum and maximum requirements in each occupation by, respectively, adding and subtracting one standard deviation to the median.
The median observed 24-h area under the concentration time curve (AUC0 24h) was 77.2 mg h/L [interquartile range (IQR) 64.7 96.2 mg h/L] for amikacin and 64.1 mg h/L (IQR 55.6 92.1 mg h/L) for kanamycin.
The median observed level of load is very close to the expected one with a very small variance for white noise.
The interval between the estimated date of infection and enrolment did not exceed 6 months (median observed interval in the cohort = 46 days).
When we compared the results from these simulations to the theoretical models, we found that for directional change (trend) the median observed load was slightly higher than expected (Fig. 1).
The median observed terms were 24 months (from 3 to 107 months).
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The four ubiquitous species (T. caespitum, L. neoniger, S. molesta, and N. flavipes) were found to coexist on almost all of the medians observed.
Studies were then grouped into "lower" (< = 20%) or "higher" (>20%) background prevalence, based on the medians observed (use of a cut-off of 10% prevalence gave very similar results, results not shown).
This prediction was compared with the actual medians observed when using updated survival data reported at least five years later.
Average total costs varied considerably, with $90,272 (median $51,004) observed among cases and $25,746 (median $12,327) among non-cases.
Nevertheless, we believe that an FE rate of 14%, the median rate observed in the interventional and observational studies described above, is inappropriately high.
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