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Red bars indicate the median mutation frequency (n = 12 126 colonies).
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The median mutation allele frequency across all patients was 17%90%0% of the frequencies were between 3.2% and 50%).
The median KRAS mutation frequency of all GC cohorts was 6.5% (range: 0%–36%) and was only slightly lower in the non-Asian GC (median 4%, range 0%21%%) compared with Asian GC (median 6%, range: 0%–36%).
Using the median mutant frequency by the method of Drake (1991), this median frequency indicated that purR mutations form at a rate of 1.3 × 10−6 mutations per cell per division (Table 2).
In the mutated cases, the mutation frequency ranged from 2.1 11.7%.
The somatic mutation frequency per megabase (MB) ranged from 10 45 with a median around 25.
MNSp, median number of non-silent mutations per patient; NS freq, non-synonymous mutation frequency among samples; S, number of samples.
These characters are believed to increase mutation frequency and mutation spectrum of plants or mammalian cells irradiated by heavy ions.
A similar behavior is seen with mutation frequency dependent on particle fluence.
We found that there was almost no effect of microgravity on DNA replication and mutation frequency.
Table 1 GP properties Parameter name Parameter specification Population size 500 Mutation frequency 93% Crossover frequency 50% Number of replication 10 Block mutation rate 30% Instruction mutation rate 30% Instruction data mutation rate 40% Homologous crossover 95%.
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