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Polynomial regression was used to calculate the median lethal dose.
Acute toxicity bioassays were conducted to determine the median lethal dose (LD50) of each insecticide for the honeybees.
They displayed a wide margin of safety with Protective index (PI), median hypnotic dose (HD50) and median lethal dose (LD50) much higher than the standard drugs.
The median lethal dose (LD50) of Te NRs and potassium tellurite (K2TeO3) were determined in mice and the subacute toxicity was also evaluated.
The corresponding median lethal dose was 107 nmol/L in serum-free media and 650 nmol/L in media supplemented with 1% FBS.
Similar measurements can be used as a rough estimate of drug toxicity, the result being expressed as the median lethal dose (LD50), which is defined as the dose causing mortality in 50percentt of a group of animals.
Median lethal dose.
The effective therapeutic dose was taken as one tenth of the median lethal dose (LD50 >2.0 g/kg) [13].
The results of three independent assays were plotted onto a fitted curve to obtain median lethal dose (LD50) values.
Acute toxicity studies are usually done to establish the median lethal dose (LD50) of a substance [8].
The oral LD50 (median lethal dose) of DAOA, OA and ODA were determined by Horn's method [27].
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