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An open-label US study of 50 subjects injected with Juvéderm® Ultra (Allergan, Inc, Santa Barbara, CA) had a median injection volume of 1.6 mL for initial treatment and 0.6 mL for top-up treatment, 2 and the pivotal study for a US lip indication for Restylane® (Medicis Pharmaceutical Corporation, Scottsdale, AZ) had a mean injection volume of 2.85 mL for initial and top-up treatment combined.
The median injection time was 20.5 s (range 2 116 s), with 73% of patients having injections within 30 s.
In the group of patients with extratemporal lobe epilepsy, the median injection time was 19.5 s (range 1 64 s) with a median seizure duration of 47.5 s (range 16 219 s).
In clinical trials, the median injection number at which a PDSS event occurred was 21 [ 6].
Median injection number at which an event occurred was the 21st injection.
During the follow-up, a median of three injections (mean 3.2; range, 1 to 10) was administered, with a median injection frequency of 11.6 weeks (mean 14.6 weeks).
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Six injections (median) were administered in the 0.3 and 1 mg groups, whereas only five (median) injections were administered in the 3 mg group.
The median monthly injection frequency was 20 (Table 1).
Extensive kindling by CL injections with a median of 97 injections (overkindling) subsequently resulted in the recurrence of spontaneous seizures in rhesus monkeys with frequency patterns that were similar to those observed in human TLE.
A cycle consisted of 6 weekly injections and the median number of injections was 12.
Quantitative assessment of tumour and measurable normal tissue uptake of antibody by SPECT at each imaging time is shown in Figure 4. I-hDFM localised to the tumour within 2 h of injection (median 4.0% i.a. kg−1) and tumour uptake reached a maximum median level of 4.1% i.a.a
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