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We then calculated the ratio of the median increments.
In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16 30]; year 2, 25 pg/mL [16 30]; ND, 9 pg/mL [5 16]; P = 0.001 and P < 0.001, respectively).
As shown in Fig. 1, in years 1 and 2, the peak increments in plasma glucagon levels during the MMTT (21 pg/mL [16 30] and 25 pg/mL [16 30], respectively) were significantly greater than median increments in ND children (9 pg/mL [5 16]; P = 0.001 and P < 0.001, respectively).
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The median increment in cortisol was 4.1 μg/dl.
Median increase (response) in mg dl−1 per mg kg−1 bodyweight of fibrinogen was calculated, and also the median increment (g litre−1) per 1 g fibrinogen concentrate administered.
The median stimulated cortisol value was 22.4 μg/dl (range 4.7 70.0 μg/dl) and the median increment in cortisol was 7.1 μg/dl (range 0.2 25.6 μg/dl).
The median increment in total insulin requirement during pregnancy was based on each patient's change in insulin dose from before pregnancy until 33 weeks.
For rare variants with OR = 10 and frequency ≥0.005, the median increment in AUC varied between 0.01 and 0.05 depending on the value of the baseline AUC.
For example, the ratio of median increment at dose-level 3 was the ratio of the median dose at level 3 over the median dose at level 2 across the studies which included at least these both dose-levels.
Median salivary cortisol values collected on the control day (samples 3 and 4) were 3.42 nmol/l (range 0.67 15.36) and 2.83 nmol/l (range 0.50 15.35); the median increment hence was approximately 23%.
The median increment in total insulin requirement during pregnancy tended to be higher in twin pregnancies compared with singleton pregnancies (a median increase of 103%[36 257%%] versus 71%[−20toto 276%]), giving a 45% higher increase in the twin pregnancies (P = 0.07).
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