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Second, even when average or median effect sizes of products appear similar, treatment responses in individual patients may differ from one drug in a class to the next, owing to known or unknown individual patient characteristics.
Further, sex-stratified genetic analyses identified associations with significantly higher median effect sizes than sex-combined analysis for girls (p-value = 6.5E-15 6.5E-15r boys (p-vande = 1.0E-7).
With a few exceptions, the mean and median effect sizes for the worsening and improvement groups met standard criteria for medium or large effect sizes.
The mean and median effect sizes for number of vomiting episodes was 0.83 and 0.88, respectively, and the same for mean severity of nausea was 0.49 and 0.29, respectively.
For number of days of vomiting or nausea, the mean and median mean difference was 0.65 and 0.55, respectively, and mean and median effect sizes were 0.28 and 0.23, respectively.
However, median effect sizes were small.
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For example, the median effect size was 1.42 across cases.
The median effect size was 1.46, which corresponds (on some reasonable assumptions) to a decrease in aggression of about one quarter.
The median effect size reported in this article is d = 0.72.
Although median effect size was correlated with between-site reliability, dissociations were observed for many voxels.
The mean and median effect size for number of vomiting episodes was 0.88 and 0.60, respectively, and the same for mean severity of nausea was 0.36 and 0.38, respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com