Sentence examples for median effect model from inspiring English sources

Drug interactions were analyzed using CompuSyn 3.0.1 (ComboSyn, Inc.,Paramus, NJ), which is based on the median effect model of Chou and Talalay [ 23].

The pharmacologic effect of an antiretroviral drug on viral replication in in-vitro assays has been described with non-linear sigmoidal models, such as the Median-Effect model by Chou and Talalay [ 9].

Equation 5 is in the same form as the Median-Effect model (equation 1) where the Hill coefficient is similarly equal to m (and may reflect the order of the reaction or molecular level cooperativity).

Each mutant is affected according to the median-effect model [ 47] (21) β i = β 1 1 + D t I C 50, i m where IC 50 is the median-effect dose and m is the Hill coefficient.

These properties reflected in pharmacodynamic parameters are obtained through the empirical fitting of models, such as the Michaelis-Menten or Median-Effect models of enzyme kinetics, to experimental data [ 10].

The uncertainty measured by the median si2 from the fixed effect model was 0.008.

The Chou–Talalay median effect and combination index (CI) model was used to determine if there was synergism between epigenetic modifiers and cisplatin (Chou, 2010).

They were derived from median effect analysis, according to independent action model, for three different levels of toxicity and three alternative schedules of administration.

Synergistic efficacy was subjected to median effect analysis with the mutually nonexclusive model using Calcusyn1 software.

Each dose response curve was fit to a linear model using the median effect equation, allowing calculation of a median effect value Dm (corresponding to the IC50).

The combined effects of TC extract and 5-FU were subjected to median effect analysis with the mutually nonexclusive model as previously described [ 30].