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Using the median effect method showed that phenanthrene and GTP were antagonistic when the inhibitory levels were less than about 50%.
HL-60 myeloid leukemia cells were used for in vitro studies of the combination of JS-K with daunorubicin (DAUNO), cytarabine (ARA-C) or etoposide (ETOP) using the median effect method to determine synergistic, antagonistic, or additive effects.
The antiviral EC50 and cytotoxic concentrations (CC50,) was determined from the concentration response curve using the median effect method [20].
To determine whether the combination of cisplatin and 17-AAG in A549 or GLC-82 cells resulted in synergistic effects, the median effect method analysis of Chou and Talalay was used [17].
We further analysed drug interaction employing median effect method.
The combination index (CI) of fluvastatin and celecoxib was calculated using the median effect method (Chou and Talalay method).
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The dose response curves of the inhibitors tested for the different cell lines and measured variables were fitted and plotted in GraphPad Prism 6. Cooperativity between inhibitors tested in combinations were calculated according to the Median effects method [ 54] using the CalcuSyn software (Biosoft).
Data were analyzed by the median-effect method (CompuSyn software; Biosoft, Ferhuson, MO, USA) to determine the drug concentrations resulting in 50% growth inhibition (IC50).
Based on the median-effect method, the combination therapy of jasminoidin and ursodeoxycholic acid had a synergic effect on reducing the infarct volume.
The dose-effect curves of single or combined drug treatment were analyzed by the median-effect method [33], [34], where the combination indexes (CI) less than, equal to, and greater than 1 indicate synergistic, additive, and antagonistic effects, respectively.
The dose-effect curves of single or combined drug treatment were analyzed by the median-effect method of Chou and Talalay using the Calcusyn Software (Biosoft, Cambridge, United Kingdom)[32] [34].
More suggestions(15)
median effect analysis
median imputation method
median polishing method
median effect principle
median effect technique
median effect size
median split method
median scaling method
median effect plot
median effect equation
median effect concentration
median filtering method
median polish method
median t method
median effect model
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