Sentence examples for median effect equation from inspiring English sources

Each dose response curve was fit to a linear model using the median effect equation, allowing calculation of a median effect value Dm (corresponding to the IC50).

This software calculates the median effect dose, Dm (analogous to the IC50), of the drug combinations using the median effect equation.

Chou and Talalay derived the combination index (CI) and median effect equation (MEE) in 1984, and have since established precedents for analyzing synergism.

This methodology is based on the median effect equation correlating drug and its effects and is used to derive an accurate value of relative potencies of different drugs (e.g. IC50 etc).

The median effect plot (based on the logarithmic form of Chou's median effect equation) forms the basis of quantification of synergism, summation and antagonism of drug combinations: log (fraction affected/fraction unaffected) vs. log (Dose).

IC25 and IC50 values (i.e. the concentrations yielding 75%and50%0% cell survival fractions, respectively) were calculated according to the median effect equation and analysis of the interaction between DOX and TPL was performed as described by Chou & Talalay [ 18].

The median-effect equation (MEE) of the mass-action law and the combination index (CI) theorem have been used for quantitative determination of synergism (CI <1), antagonism (CI >1) and additive effect (CI = 1) in animals in vivo.

In 1976, he introduced the Pharmacodynamics/Biodynamics General Theory and the Median-Effect Equation of the Mass-Action Law, as the Unified Theory for BD/PD.

Here, the central assumption is that the median-effect equation [12], [32], [33] is coupled linearly to a cell-killing rate under treatment.

To quantitatively validate the synergistic nature of the interaction between thiostrepton and bortezomib, we examined cell viability after single and combination drug treatments by using the Chou-Talalay median-effect equation method [8].

Combination drug experiments were assessed for synergy, additivity or antagonism using Calcusyn (Biosoft, Cambridge, UK), which uses the median-effect equation of Chou and Talalay.