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The cytotoxic effects of combination treatment were determined by median effect analysis.
We have investigated the potential synergistic effect of combining demethylcantharidin with a platinum-based antitumor agent, such as cisplatin, carboplatin, or oxaliplatin in vitro against L1210 mouse leukemia and SK-Hep-1 human hepatocellular carcinoma, and in vivo against a SK-Hep-1 subcutaneous-inoculated xenograft in nude mice, using median effect analysis.
They were derived from median effect analysis, according to independent action model, for three different levels of toxicity and three alternative schedules of administration.
Median effect analysis characterized the interaction between NO-Cbl and the chemotherapeutic agents[38].
Median effect analysis was used to characterize the interaction between NO-Cbl and various chemotherapeutic agents[38].
Drug synergy was determined from median effect analysis by Chou-Talalay equations [31] using the CalcuSyn software (Biosoft).
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Interactions with other therapeutic agents were evaluated using median effects analysis.
The results were analyzed using the median effects analysis of Chou and Talalay [36], and the combination index (CI) derived using the Calcusyn software program (Biosoft, Cambridge, United Kingdom).
The nature of the interactions between these compounds and gemcitibine, 5-fluorouracil, or camptothecin was evaluated using the median effects analysis of Chou and Talalay, and the combination index (CI) derived, with a CI<1 indicating a synergistic interaction.
The IC50 values of AZT and CdA were calculated by using median-effect analysis and CalcuSyn software.
For the median-effect analysis, the compounds were combined at several ratios based on multiples of their EC50 or EC90 values.
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median distance analysis
median polish analysis
median network analysis
median effect equation
median effect plot
median survival analysis
median effect concentration
median frequency analysis
median split analysis
median neighborhood analysis
median effect method
median effect model
median laboratory analysis
median normalization analysis
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