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The most active compound 4g effectively suppressed seizure effect in both the animal models with median doses of 15.6 mg/kg (MES ED50), 278.4 mg/kg (scPTZ ED50) and 534.4 mg/kg (TD50) with no sign of neurotoxicity.
N- 6-methoxybenzothiazol-2-yl -4-oxo-4-phenylbutanamide (2f) emerged as the most effective aN- 6-methoxybenzothiazol-2-yl -4-oxo-4-phenylbutanamide0), 85.16 mg/kg (scPTZ ED50) aN- 6-methoxybenzothiazol-2-yl -4-oxo-4-phenylbutanamide
Median doses of antifungal agents are reported in additionnal file 1.
The text in additional file was as follows: At SAT initiation, the median doses of fluconazole, voriconazole, caspofungin and micafungin were 800 mg, 800 mg, 70 mg and 100 mg, respectively.
Median doses of the lipid lowering agents were used as cut-offs in these calculations (high dosages: simvastatin ≥20 mg, pravastatin ≥40 mg, fluvastatin ≥40 mg, atorvastatin ≥20 mg, rosuvastatin ≥10 mg as high dosage, fibrates ≥0.5 mg; all used 10 mg ezetimib).
The median doses of drug doses are calculated for number of patients receiving aforementioned drug.
Similar(30)
Seventeen tumors received a single fraction with a median dose of 20 Gy (range, 18-30 Gy).
The patients had received a median dose of 66 Gy of external beam radiotherapy and 72% underwent chemotherapy.
In all, 50 of the patients were previously irradiated to a median dose of 40Gy in 2-3Gy frandions and 3 patients developed treatment-related myelopathy.
In 10 patients with gastric variceal bleeding, a median dose of 6 mL of Beriplast-P was injected into gastric varices.
The median dose of amikacin was 30 [29.2–30.6] mg/kg.
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