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Additionally, significance was tested for with confidence intervals around median differences using script for permutation tests (SAS 9.0; SAS Institute, Cary, NC, USA).
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In addition, data from individual food diaries, obtained at a single timepoint were used to group women with calcium intakes above and below the median to investigate group differences using conditional regression analysis.
Agreement between child self and parent proxy-report on the PedsQL™ 4.0 was assessed using ICC values and median difference testing using Wilcoxon significance tests.
Group differences were assessed using unpaired t-test (single comparison) or ANOVA/linear regression (multiple comparisons/change with time) with the exception of individual worm mtDNA copy number, which failed normality test and, therefore, median differences were analysed using non-parametric test (Mann-Whitney test).
Confidence intervals for median differences were calculated using the Hodges-Lehman method.
Point estimates of and nonparametric 95% CIs for median differences were calculated using the method of Walsh averages.
Otherwise, the median values were analyzed for significant difference using Mann-Whitney test.
Table 2 Comparison of median differences between Virgan use and no Virgan use Virgan on vs Virgan off: Median IQR p value No. of episodes of uveitis recurrence per person year −0.88 [−5.49–0.029 0.029 Days-to-quiescence per episode of uveitis −1.25 [−8.75–37.29] 0.610 Days-to-recurrence per episode of uveitis −143.75 [−422.5–144.75] 0.285.
The seventh decision tree that had the largest percent difference in ICUR from the base case was the scenario using the median difference between US and Japan weights, while the third decision tree that had the smallest percent difference in ICUR from the base case was the scenario employing the mean difference between UK and Japan weights.
Wilcoxon Mann–Whitney Rank Sum tests (non-parametric) were used to test median differences while the T-test was used to test differences in means for normally distributed data.
Gene Set Matrix Analysis (GSMA) [24] was performed using the median differences for differentially expressed genes tested against genesets derived from a variety of sources (for example, the Pathway genelists were originally obtained from the Gene Set Enrichment Analysis (GSEA) website maintained by the Broad Institute @ (www.broad.mit.edu/gsea).edu/gsea
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