In fact, TRAIL treatment induced a 16% median decrease in viability in non-del 8p) non-del 8pP=0.05; one-sided paired t-test) controls with only a 5% median decrease in del(8P=0.05 samples (P=0.12).
The median decrease in steroid dose at 1 year was 61.6%.
The median decrease in the tibial sesamoid position was 5 (range 2 6).
In a phase I/II study of rasburicase in children and young adults with hematological malignancies, rasburicase was demonstrated to be well tolerated at 0.2 mg/kg/day intravenously, had a mean T1/2 of 21.2 ± 12.0 hours, and induced a median decrease in uric acid from 9.7 mg/dL to 1.0 mg/dL (P < 0.001).
The median decrease in postoperative serum creatinine level (> or = 7 days after operation) was 0.81 +/- 0.05% (mean postoperative serum creatinine level 1.27 +/- 0.07 mg/dl).
In all animals, after bacterial challenge, the median decrease in MAP, within 24 h, was 9.89 % (range 1.36 20.6 %) (Additional file 1: Figure S2).
The median decrease in hemoglobin concentration on the first postoperative day was 2.6 ± 1.16 g/dl in the fibrin tissue adhesive group and 3 ± 1.28 g/dl in the control group.
The median difference between i-Hb and r-Hb in these 18 patients was 1.21 g/dl (IQR = 0.77 to 1.53) and the median decrease in Hb concentration was 8.52% (IQR = 5.45 to 11.12).
Finally, at 1-year follow-up, 18 patients (37%) displayed a good outcome with a median decrease in mRS of −1.5 [−2 to 0] as compared with ICU discharge.
Among the patients with good outcome at ICU discharge (n = 14), one died, seven further improved their outcome at 1 year with a median decrease in mRS of −2 [−2.0 to −1.0], whereas one patient deteriorated while remaining in the good outcome group (from mRS 1 to mRS2) and six remained unchanged.
Among the patients with good outcome on ICU discharge, one died, seven further improved their outcome at 1 year with a median decrease in mRS of −2 [IQR −2.0 to −1.0], whereas one patient deteriorated while remaining in the good outcome group (from mRS 1 2).
