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Our analysis of bacterial burden showed a median decrease from 1190 copies of ospA in wild type mouse bladders down to 526 copies in Nod2 deficient bladders and from 11,550 copies in wild type hearts down to 4,475 copies in Nod2 deficient hearts (p = 0.0335 and 0.0155) (Figure 7).

The median decrease from baseline in synovitis score for CZP patients was numerically higher compared with placebo→CZP patients at weeks 1 16, but the differences were not statistically significant.

The median decrease from baseline in CgA concentration was significant after 8 weeks (−35%; range, –91.8 to −7.8%; Wilcoxon's test: p < 0.001); median decreases varied from −31%to−17%7% at subsequent assessments, although not all reductions reached statistical significance.

We observed a median decrease from the native load, from 54 N (95% CI: 28 N–91 N) to 48 N (95% CI: 24 N–82 N) upon arthrodesis; regarding intraarticular peak pressure, we saw a change from native 3.3 MPa (95% CI: 2.7 MPa–4.4 MPa) to 3.4 MPa (95% CI: 2.6 MPa–4.2 MPa).

Furthermore, when looking at total serum cholesterol levels, there was a 12% median decrease from baseline in total cholesterol in the tamoxifen arm after 6 months, consistent with previous reports demonstrating the lipid-lowering effect of tamoxifen [ 67], while in the letrozole group total cholesterol values remained stable [ 8].

Among this cohort of patients, Dermatology Life Quality Index (DLQI) data showed a significantly greater median decrease from baseline in ustekinumab-treated patients than in placebo-treated patients at week 12 (−6.0 [interquartile range −14.0 to −3.0] versus 0 [interquartile range −4.0 to 2.0], respectively).

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Similar(53)

The median decreased from 1 to 10 and the range of similarity became broader.

CD4+CD69+ activated lymphocytes did not change after vaccination in PT stimulated cultures and decreased in FHA (median decreased from 0.70% to 0.48%, P = 0.0141), in PRN (median decreased from 0.82% to 0.54%, P = 0.0195) and FIM (median decreased from 0.77% to 0.57%, P = 0.019) stimulated cultures.

In the placebo group, the median decreased from 454 to 68 pg/mL.

BV/ER-treated patients showed a significant decrease in plasma VEGF levels after 7 days (median decreased from 134 to 25 pg ml−1, P=0.002, data not shown), probably because the used ELISA-kit measures only free VEGF (Loupakis et al, 2007).

For the lower educated patients the median decreased from 4 to 2 and for the higher educated patients from 4 to 3. Table 2 shows the results of the analyses relating the hypoglycaemic events (dependent variable) to educational level (independent variable) when the number of hypoglycaemic episodes was treated as normal, Poisson or binomial/Poisson (two-part joint) distributed.

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