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Finally, the number of days alive without SAT at day 28 was higher in the de-escalation group (14 days [5; 23]) than in the no de-escalation group (10 days [2; 17] p < 0.01) leading to a median cost difference of 1100 euros in favor of de-escalation group.
Second, although we report a median cost difference between modalities among our centers, our primary goal was not to determine average costs.
We estimated the median cost difference between CRRT and IRRT across all centers to be $289.60/day (IQR, 830.80 - 116.8) per day (greater with CRRT).
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The median cost differences between fracture sites were all statistically significant.
Quantile regression will be used to examine and compare the median cost differences.
The median cost differ statistically according to the Mann-Whitney U-test, but the confidence interval as provided through bootstrapping does not show a difference in the mean costs (€-76€-76€21).
The median price difference is an astounding 46percentt".
Soo et al [ 46] found no significant difference in total median cost between CAM and conventional therapies (31.7 US$ vs 50.0 US$ per month).
The median cost of DMT1 was higher than DMT2 (USD 748 vs. USD 140), however this difference was not statistically significant (p = 0.167 [ 37]).
Interestingly, in our study, the median cost per patient without response was higher than that of a patient with response, although the difference was not statistically significant.
Effect estimates were calculated by subtracting the individual event-free survival from the median event-free survival and dividing the difference by the median event-free survival and cost estimates by subtracting the individual costs from the median costs and dividing the difference by the median costs.
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