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Small median changes from double-blind baseline were also observed at months 12 and 24 in metabolic parameters and prolactin (Table 3).
It becomes obvious that if histogram changes from a starting shape to a shape, its CF changes from to, which can considerably change the position of the median (the median changes from to ).
The statistical evaluation of pharmacodynamic parameters provided median changes from baseline per time point.
The median changes from baseline to last value on treatment were small and similar for total cholesterol and HDL cholesterol.
There were no clinically meaningful median changes from baseline in laboratory, ECG or vital sign parameters across treatment groups.
The median changes from baseline in body weight in Quartiles 1 4 were −6.0, –3.0, −1.0, and +1.0 kg, respectively.
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aDenotes statistical significance of the observed median change-from-baseline value with P ≤ 0.05 by Wilcoxon signed rank test.
From 1979 through March 2009 — the last month to have a benchmark revision — the median change from the first number to the final one was up or down 71,000 jobs.
The primary end point, median change from baseline in SBMs per week after week 1 of drug administration, was statistically significant for the 25- and 50-mg naloxegol cohorts vs placebo (2.9 vs 1.0 [P = 0.0020] and 3.3 vs 0.5 [P = 0.0001], respectively).
Fig. 5 Median change from baseline in a plasma MMP-7, b surfactant protein D, and c tenascin-C in all treatment groups throughout the 56-week study Fig. 6 Median change from baseline in a plasma MMP-7 concentration at week 4 versus CC-930 dose and b MMP-7 versus CC-930 exposure (AUC0−τ) predicted from the population pharmacokinetic model.
In the pooled cohort, median change from baseline to last observation was -1.0 (interquartile range -2.0; 0.0) point for INCAT score; +8.0 (0.0; 20.0) kPa for maximum grip strength; +3.0 (1.0; 7.0) points for MRC sum score.
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