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The median duration of follow-up was 2.2 years.At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001).
A large factor in explaining this paradox is that the median baseline value for water access was much higher compared to that of sanitation (59% vs. 28%).
In the subgroup of patients with baseline A1c values below the overall median baseline value (ie, better-controlled diabetes), the mean baseline A1c was 6.2% (n = 253).
In the subgroup of patients with A1c values above the median baseline value (ie, less-controlled diabetes), the mean baseline A1c was 7.6% (n = 261).
The previous observational studies have shown that the mean or median baseline value of lipoclalin-2 is highly contradictory dependent on the study design and assay method [ 21, 22].
Bleeding time was modestly prolonged compared with placebo; from a median baseline value of 165 seconds, a 1.1- to 3.3-fold increase in bleeding time was seen after administration of ticagrelor versus a 1.1- to 1.2-fold increase with placebo.
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Median baseline values of each biomarker were used to categorise patients as high or low.
Median baseline values were compared for children with (n = 150) and without (n = 150) asthma.
Table 4 describes, for each cytokine analysed, median baseline values and median changes from baseline, week 8 and at week 17.
The median baseline values and mean change from baseline at 52 weeks for these parameters were similar in the omalizumab and placebo group (Table 4).
The median baseline values have different locations in their respective scoring ranges: the median EQ-5D score was located in the top quarter, the median SF-6D in the middle part.
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median baseline seizure
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median baseline homocysteine
median baseline A1c
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median baseline bodyweight
median baseline concentration
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median home value
median baseline hemoglobin
median baseline plasma
median baseline hs-CRP
median baseline age
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