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First, the CV is lowest at the median baseline level and increases toward the extreme values in both directions, as expected.
Once markers were identified, a traditional statistical approach to assess the prognostic value (across both study arms) and predictive value (comparing sensitivity of patients on the cediranib arm with placebo) of each biomarker was used: the biomarker values were dichotomised into high and low categories based on the median baseline level for each marker.
From a median baseline level of 63 pg/ml (range 17 591; n = 66), the median post-NACT value had increased to 213 pg/ml (range 59 875; n = 66) with further rise to 309 pg/ml (range 48 1226; n = 54) in the post-CRT samples.
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(B) Patients according to dichotomized baseline levels of BMI (< or ≥25 kg/medianedian baseline levels of HbA1c (≤ or >9.15%) or of total daily insulin dose (< or ≥0.72 U/kg).
In the vaccine group, median LPS specific IgG antibody levels were 66650 (IQR; 31075 123900) units/ml and 55700 (IQR; 25450 106800) units/ml on day 14 and 28, respectively, compared to median baseline levels of 6300 (IQR 3620 16560) units/ml.
Also, for HbA1c, interactions by study drug treatment were not significant in subgroups of patients categorised by baseline levels of BMI, median baseline levels of HbA1c, total daily insulin dose, or by evidence of substantial changes in the insulin regimen during the trial (data not shown).
The analytes, including their median baseline levels, minimum/maximum values and standard deviation, are shown in Supplementary Table 1.
Median baseline levels for CTx, osteocalcin, BSAP, P1NP, and vitamin D were all within the normal range.
Smokers (N = 50) also presented with higher median baseline levels of CRP (4.1 (3.0 7.8) vs. 2.6 (1.6 7.1); P = 0.001), but with no differences in the other biomarkers.
The inclusion criterion with regard to haemoglobin level was 8.0 10.0 g dl 1, and the median baseline haemoglobin level was 9.4 g dl 1 in the EPO group and 9.3 g dl 1 in the placebo group.
The median baseline ST2 level was 23.7 ng/mL (interquartile range, 18.6-31.8).
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