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The intimal tear extends to a variable degree within the aortic media without significant separation of the medial layers and does not result in a second flow channel, as seen in classic AD [13].
'Cystic media necrosis' is the common end path of various acquired and genetic conditions weakening the medial layers of the aorta leading to the breakdown in the integrity of the aortic wall, which precedes AD [10].
Another variant of AD called limited intimal tear or discrete/subtle tear is characterized by a complex primary intimal tear with only minimal separation between the medial layers at the edges of the lesion; this disease entity also has a pathophysiology and etiology overlapping with classic dissection [9, 13, 14].
The extreme within the spectrum of separation of medial layers as a consequence of underlying 'cystic media necrosis' occurs in complete thrombosis of the false lumen, resulting in the imaging features of IMH, and in this context, IMH is considered a variant of classic AD.
Currently, it is accepted that IMH can be a variant or a precursor of AD, and many have regarded IMH as synonymous with a 'thrombosed type' or 'non-communicating' AD (Fig. 4) [15, 21] where separation of the medial layers still occurs, but this is filled with thrombus rather than flowing blood in what would otherwise be the false lumen of a classic dissection.
Figure 2A shows that a stronger immunoreactivity of PDE10A was observed in lung specimens from MCT-PH rats, which suggests that the site-specific change of PDE10A expression was induced in pulmonary hypertensive lungs, especially in the medial layers of pulmonary arteries.
Similar(32)
Aneurysm, widening of an artery that develops from a weakness or destruction of the medial layer of the blood vessel.
The medial part of the VI aponeurosis separates into a superficial and deep medial layer.
Degeneration of the medial layer of the aortic wall is the fundamental pathophysiology of AD [8].
EC adhesion was not enhanced by addition of FN, collagen I, collagen IV or laminin (LN) to the medial layer.
As an example, the medial layer of a human abdominal aorta is investigated, modeled by some of the proposed polyconvex functions and compared with experimental data.
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