Exact(3)
SMO aims to alter the joint mechanics in a varus ankle by correcting the medial displacement of the load line and shifting the medial concentration of the stress laterally onto the intact articular cartilage of the lateral side within the ankle (Becker and Myerson 2009; Castagnini et al. 2016; Cheng et al. 2001).
The postoperative contact pressure profile showed overcorrection of the joint alignment, resulting in medial concentration of the peak contact pressure.
As Cdr2 medial concentration increases with cell elongation, it is proposed that the Cdr2 concentration at the SPB would increase until it is sufficient to inactivate Wee1.
Similar(57)
Relatively large intraruminal differences of VFA concentrations and pH between the ventral and medial pools were observed, VFA concentrations being largest and pH being the lowest medially.
For example, animal studies have shown an increase in medial prefrontal cortical glutamate concentrations after clozapine administration, while haloperidol did not elicit this increase [48].
DOI: http://dx.doi.org/10.7554/eLife.02040.004 10.7554/eLiFigure40.005 Figure 1 figure supplement 2. Pom1p concentration at the medial cortex: Comparison with previous data.
As cells grow and elongate, Pom1 concentration at the medial site becomes progressively lower, Wee1 is eventually inhibited by Cdr1/Cdr2, and cells commit to mitotic division [ 47, 48].
The authors suggest that Cdr2 localization at the medial cortex could generate a concentration gradient that extends to the SPB where the Cdr2 target Wee1 resides.
DOI: http://dx.doi.org/10.7554/eLife.02040.003 10.7554/eLiFigure40.004 Figure 1 figure supplement 1. Pom1p concentration at the medial cortex does not vary with cell length.
Given that the authors know both the Cdr2 concentration at the medial cortex and the turnover rate they could calculate how steep the gradient from the cortex is likely to be and whether the concentration of Cdr2 around the SPB would actually change significantly as cells elongate.
The hippocampus, amygdala and medial prefrontal cortex have high concentrations of GRs [ 8- 10].
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