Sentence examples for mechanistically integrated from inspiring English sources

A mechanistically integrated method for the identification of CNS tracer candidates was developed in which the non-specific binding, tracer affinity, and the target protein expression in the brain were taken into account.

Figure 4 compares the venous blood concentrations predicted by the whole-body PBPK and the compartment model with mechanistically integrated covariates for a single individual (left) and a larger virtual population (right).

This study presents a mechanistically integrated approach for effective identification of PET tracer candidates based on simple and well-established theory.

In an effort to simplify this process, we herein propose a mechanistically integrated approach for the selection of tracer candidates based on in vitro measurements of ligand affinity (Kd), non-specific binding in brain tissue (Vu,brain), and target protein expression (Bmax).

This review proposes two new targets that may mechanistically integrate inflammation and metabolic syndrome, have been largely ignored, and are known to be druggable.

These observations suggest that hypoxia responses integrate mechanistically with longevity-associated cellular processes.

The patient-specific information generated within VLN is integrated in PBPK models, thereby mechanistically relating a patient's physiology to the emerging pharmacokinetic profile.

A comparison of the genome with that of another H aloquadratum walsbyi strain (DSM 16854) isolated from Australia revealed a putative, mechanistically coupled insertion and deletion system, causing different sequences to be integrated at exactly the same position on the chromosome (Dyall-Smith et al. 2011).

With the aim of mathematically investigating this therapeutic failure, we developed a mechanistically based model which integrates cell cycle regulation and macroscopic tumor dynamics.

To understand how stroke risk factors mechanistically contribute to stroke, the genetic components regulating each risk factor need to be integrated and evaluated with respect to biological function and through pathway-based algorithms.

In the present study we measured the integrated AhR mediated activity in the lipophilic serum fraction containing POPs using the mechanistically based AhR-CALUX bioassay.