The Notch protein is one of the most mechanistically direct transmembrane receptors the intracellular domain contains a transcriptional regulator that is released from the membrane when engagement of the cognate extracellular ligand induces intramembrane proteolysis.
Mechanistically, direct uptake of these remnant lipoproteins by macrophages stimulates cholesterol ester accumulation and macrophage foam cell formation, an important step in fatty streak formation [32].
Having demonstrated mechanistically how direct stimulation of endothelial cells with dsDNA results in the expression of adhesion molecules, we next sought to investigate whether dsDNA induced TNFα production.
Mechanistically, a direct effect to a mesothelial cell, such as mutagenic or clastogenic effect, would favor a dose-dependent acceleration of the onset.
Since there is not enough data in the literature to justify, mechanistically, the direct involvement of UFP in receptor activation, we assume, in this context, the standard activation model without UFP involvement.
While many studies have focused mechanistically on direct positive effects of warming or resource enhancement on invasive species (Bradley et al. 2010), there is growing recognition that climate change could facilitate invasions because of the distinct phenology or phenological sensitivity of non-native species (Willis et al. 2010; Wolkovich et al. 2013).
We compare below the polymorphic toxin systems with several of these systems and discuss the potential importance of significance of the similarities and differences: 1) Effectors directed at hosts and distantly related competitors: Mechanistically the polymorphic toxins and the effectors directed against hosts and distantly related competitors are closely related.
Our efforts, and also those of many other research groups, have been directed at the development of catalysts for the energetically demanding and mechanistically complex water oxidation reaction (2H2O ⇌ O2 + 4H+ + 4e−) which can be coupled with catalysts for proton reduction (2H+ + 2e− ⇌ H2) to achieve water splitting.
Understanding how the amygdala mechanistically interacts with regions involved in vicarious activations to direct this scenario remains to be understood.
