From the mechanistic viewpoint, they mostly act as exchangers: OATs exchange organic anions for dicarboxylates, 1091) OATPs exchange organic anions for bicarbonate, glutathione, or glutathione-S-conjugates, 1092) and OCTs and OCTN1 exchange organic cations for protons.
We also suggest a new mechanistic viewpoint that helps to explain the disease process and provides a platform for developing new treatment modalities.
This selectivity engineered PTC reaction has been investigated from mechanistic viewpoint and the rationale of selectivity is delineated.
It is reasonable to propose, from a mechanistic viewpoint, that the reason YopJ cannot bind to IKKα is because the binding site on the kinase is blocked.
From a mechanistic viewpoint, responses are determined by the pharmacodynamics characteristics and the exposure time course.
The circulating neutrophil and lymphocyte trends observed in this study offer an interesting mechanistic viewpoint.
They are more important from the mechanistic viewpoint, because they confirm the existence of the mixed period of distribution.
Of the pathways identified, those of potentially most interest from a mechanistic viewpoint are 'phospholipid scramblase activity' and 'phospholipid scrambling'.
Viewing the damaged perineum from a mechanistic viewpoint, as a faulty object, a disembodied or component part, had been protective and safe, while the paternalistic discourse of the feminine body as weak and inferior was confronting and upsetting.
Deviations from expected additivity are interesting from a mechanistic viewpoint, but their relevance in relation to the application of CA or DA in risk assessment practice is not well defined.
