Sentence examples for mechanistic validation based from inspiring English sources

Mechanistic validation, based on the biological knowledge and different precise interventions, would be based not only on the correlation of results of test and reference model, but on the mechanism underlying the AOP of DNT hazard manifestation (Hartung and McBride 2011; Leist et al. 2012a).

Thus, we next performed functional validation based on some of these hypothetical mechanisms using pharmacological inhibition.

The LOO evaluation is cross validation based.

The Cat-Scramble validation procedure is a cross-validation based on Fischer's randomization test.

Mechanistic validation information about fuel oxidation chemistry is also provided by the measurement of various larger carbon number alkene isomers at 830 K and 8 atm.

As alternative, a mechanistic validation has been proposed (Leist et al. 2008b, 2012b; Hartung et al. 2013).

The theoretical validation was based on cross-validation.

Fig. 3 Proportion of participants using each Maze Navigation Task strategy type based on (a) their Original Condition assignment, (b) their Mechanistic Assessment performance, and (c) their recategorized Mechanistic group based on Original Condition and Mechanistic Assessment performance.

A possible mechanistic pathway based on free energies derived from density functional calculations involving cyclic intermediates is proposed.

Figure 3 shows the proportion of participants who created each type of final strategy based on their (1) Original Condition, (2) their Mechanistic Assessment performance, and (3) their recategorized Mechanistic group (based on matching their Original Condition with their Mechanistic Assessment performance).

Although some in vitro parameters were fitted based on a test study, the use of mechanistic physiologically based pharmacokinetic (PBPK) models allowed the in vivo extrapolation of these parameters and subsequent successful prediction of PK parameters, in comparison to the validation study set.