Mechanistic testing of the Rev effect suggests it triggers transient induction of cellular oxidative stress.
If the binding of gp120 really were selectively dependent on SIGN-R1 then the authors would be in a position to perform a mechanistic test of whether antigen capture by SIGN-R1+ cells is important for induction of anti-gp120 antibody responses by immunizing SIGNR1 deficient or blocked mice.
If the binding of gp120 really were selectively dependent on SIGN-R1 then the authors would be in a position to perform a mechanistic test of whether antigen capture by SIGN-R1 + cells is important for induction of anti-gp120 antibody responses by immunizing SIGN-R1 deficient or blocked mice.
The data to be generated would include full physicochemical characterization, an array of in vitro mechanistic tests, and full traditional toxicologic test batteries.
The requirement of content neutrality is, he said, "a mechanistic test" that dishonors history and reality.
It was Coalition ministers who decided on a huge and rapid expansion of the test, in May 2011, to re-assess 1.5m existing incapacity benefit claimants, despite apparent warnings from their own expert advisor, Professor Malcolm Harrington, that the rollout should be delayed until what he described as an "inhumane and mechanistic" test could be further refined.
However, direct experimental tests of mechanistic detail at the chemical level are not easily achieved.
Until we overcome such limitations, tests of mechanistic hypothesis concerning the spatial and temporal evolutions of VALI will suffer from a blind spot.
Therefore, beyond enhancing power for association analysis, intermediate phenotypes hold the additional promise of testing mechanistic hypotheses of gene action.
DCM is a general framework for testing mechanistic hypotheses of how measured signals are generated and, in so doing, can accommodate models of different types.
