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If the binding of gp120 really were selectively dependent on SIGN-R1 then the authors would be in a position to perform a mechanistic test of whether antigen capture by SIGN-R1+ cells is important for induction of anti-gp120 antibody responses by immunizing SIGNR1 deficient or blocked mice.
If the binding of gp120 really were selectively dependent on SIGN-R1 then the authors would be in a position to perform a mechanistic test of whether antigen capture by SIGN-R1 + cells is important for induction of anti-gp120 antibody responses by immunizing SIGN-R1 deficient or blocked mice.
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Although these intensive data would provide stronger, mechanistic tests of our findings, a focus on more limited surveys of species richness was still able to elucidate broad patterns in the effects of forest fragmentation.
Mechanistic testing of the Rev effect suggests it triggers transient induction of cellular oxidative stress.
Through a screen of 2000 marketed drugs and naturally occurring compounds, and subsequent mechanistic testing, a variety of antibiotic inhibitors of mitochondrial protein translation were identified.
The requirement of content neutrality is, he said, "a mechanistic test" that dishonors history and reality.
It was Coalition ministers who decided on a huge and rapid expansion of the test, in May 2011, to re-assess 1.5m existing incapacity benefit claimants, despite apparent warnings from their own expert advisor, Professor Malcolm Harrington, that the rollout should be delayed until what he described as an "inhumane and mechanistic" test could be further refined.
The data to be generated would include full physicochemical characterization, an array of in vitro mechanistic tests, and full traditional toxicologic test batteries.
A stronger and more quantitative test of the mechanistic independence is to ask if the kinetics of one pathway are altered by blocking or accelerating the other.
Acute heat shock and mechanical stress represent a test of the mechanistic limits of the stress response and a simulation of ecological stress, respectively.
Unfortunately, the authors were unable perform the one very obvious test of their mechanistic proposal, mutation of the Arg-rich hub cavity, owing to technical problems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com