Sentence examples for mechanistic template from inspiring English sources
Furthermore, our study provides a new mechanistic template that can potentially be exploited for the development of therapeutic strategies targeted at cancer stem/progenitor cells.
In addition, mechanistic template mutation matrices (MTMMs) representing oxidative DNA damage, ultraviolet-induced DNA damage, 5mCpG deamination, and APOBEC-mediated cytosine mutation, are presented.
Therefore, the minimum factor across all elements of the MTMM represents the maximum possible contribution of that mechanistic template to the sample's SAMM.
We also derive mechanistic template mutation matrices (MTMMs) representing estimated mutation patterns putatively emanating from the four mutational mechanisms studied here: oxidative damage, UV-induced damage involving CPD formation, deamination of 5mCpG, and the action of members of the APOBEC family of cytosine deamination enzymes.
In order to investigate the complexity of the mechanistic basis for template selective recognition in these polymeric matrices, the use of a quantum chemical approach has been attempted providing new insights about the mechanisms underlying template recognition, and in particular the crucial role of the crosslinker agent and the solvent used.
Cleavage of a model phosphate ester and supercoiled plasmid DNA by a Cu(I ·adenylated polymer template and preliminary mechanistic investigations are reported.
Furthermore, based on the sequence of events in each of these pathways, a set of mechanistic reactions (i.e., template reactions [ 36]) were developed that could be applied to and individualized for every pORF (Additional file 1).
Importantly, both chaperones evict the linker histone from chromatin templates, providing a mechanistic foundation for their shared anti-repressive effects.
Genetic evidence in yeast has implicated this modification in an error-free pathway of damage avoidance that likely involves template switching, but the mechanistic aspects of the reaction are unexplored (Hoege et al. 2002; Zhang and Lawrence 2005).
Experimental observations were further discussed via the understanding of the mechanistic origin of ZnO formation onto alumina template.
Altogether, the new revised figure reinforces our mechanistic model, whereby destabilisation of the chromatin template due to the presence of H3K64ac facilitates histone eviction.
