Sentence examples for mechanistic switch from inspiring English sources

These genes are two candidates to further explore the mechanistic switch during bradyzoite formation.

The discovery of this pSer-mediated mechanistic switch which can alter LRRK2 ubiquitination and downstream stability and function could certainly widen the potential for therapeutic intervention.

Although the molecular basis for this mechanistic switch between PADs 2 and 4 is unknown, it likely relates to subtle differences in the active site architecture because the two enzymes adopt similar conformations in the catalytically competent calcium-bound state.

By exploring the consequences of LRRK2 inhibition, we elucidated dephosphorylation of the upstream kinase sites (Ser) as a mechanistic switch to alter its ubiquitination and downstream stability and function.

This suggests that each of these two pathways are sufficient to propagate cancer cell growth, with the mechanistic switch perhaps partly being explained in terms of estrogen-ERα complexes or tamoxifen-ERα complexes repressing HER2 transcription [ 55].

In addition to the genes identified by the insertional mutagenesis screen, mixture model analysis allowed us to identify a small number of genes, in mutants, for which expression patterns could not be accounted for using the three parasite states – genes that may play a mechanistic role in switching from the tachyzoite to bradyzoite stage.

Finally, we tested the mechanistic prediction that peroxisomes switch from de novo synthesis dominated production in glucose-containing medium to fission dominated production in oleic acid-containing medium.

The mechanistic details of this switch are complex with some TF being able to bind to DNA also bound by the histone octamer [ 19].

To understand the mechanistic nature of phenotypic switching between antibiotic susceptible to resistant states, the kinetics and degree of antibiotic resistance induction was evaluated upon transfer of bacterial cells from MHB (non-inducing) to LPM pH 5.5 (inducing) medium.

While these methods have been proved to be very successful on the structural studies of many macromolecular complexes and revealed important mechanistic insight to the conformational switch of important molecular machines, there are still a lot of complexes with more complicated conformational heterogeneity that cannot be easily studied.

Using a mechanistic model to identify transcriptional switch points is likely to strongly contribute to efforts in elucidating and understanding regulatory interactions within transcriptional networks.