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Our results provide mechanistic support for a "postcategorization" memory role of the FOF in upcoming choices.
These results provide mechanistic support for the idea that body condition prior to the first ocean winter is important for juvenile salmon survival.
These findings provide an important mechanistic support for ongoing clinical trials of huA33 in patients with metastatic colorectal carcinoma and provide data to rationally design them.
This effect was more marked in patients loaded with 600 mg, lending further mechanistic support for this dose of clopidogrel as a more effective antithrombotic regimen than the standard 300 mg dose.
Our findings provide mechanistic support for using TGF-β inhibitors to enhance the efficacy of tumor immunotherapy, indicate that sTGFBR3 levels could serve as a predictive immunotherapy biomarker, and expand the mechanisms by which TGFBR3 suppresses cancer progression to include effects on the tumor immune microenvironment.
The novel findings provide mechanistic support for the limited clinical observations that RAS blockade may protect against cardiovascular diseases in postmenopausal women.
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Therefore, the functional interaction of LRRK2 with dynamin GTPases is rather complex but provides initial mechanistic support of a role for LRRK2 in regulating membrane dynamics important for mediating endocytosis and mitochondrial function (14, 24– 27, 32, 36– 36).
It is easy to claim that a trait is due to natural selection, but responsible selection-based arguments should have substantial experimental mechanistic support, at least for the fact of selection.
Moreover, epidemiologic associations of a specific disease with peak exposure can be difficult to interpret in the absence of prior mechanistic support, such as the requirement for acute above-threshold exposures.
The rationale for the choice of clinical doses is not clear, but nonetheless a reduction in CSF Aβ was demonstrated in the phase 2 studies, although for this mechanistic approach an increase in CSF Aβ would have been anticipated, unless the therapeutic agent was able simultaneously to reduce aggregation and increase clearance, for which mechanistic support is lacking.
Our future study will further establish this epigenetic-genetic regulatory axis, so that novel mechanistic support and guidelines may be provided for lifestyle interventions (e.g., physical activity) through enhancing insulin sensitivity and SIRT1 activity [ 63, 64].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com