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This is the first mechanistic study in hydrocarbon flames that provides such experimental evidence.
A mechanistic study in gene and protein level indicated that focal adhesion kinase (FAK) was involved at the early stage of cell adhesion and cell cell contact-related markers, N-cadherin and neural cell adhesion molecule (NCAM), were highly up-regulated at later time point.
Rivaroxaban was safe and well tolerated; however, this was a mechanistic study in healthy subjects and safety was not the main focus.
No potential carcinogenic concern for humans was identified, which was further confirmed by a mechanistic study in nonhuman primates, employing molecular biomarkers.
The results of this mechanistic study in patients with idiopathic constipation further suggest the possible usefulness of prucalopride not only in patients with constipation but also in patients with an associated upper or generalized gastrointestinal motility disorder.
Lastly, their findings from the mechanistic study in this investigation suggest that the antioxidant effect of CUR is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1 [ 63].
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Mechanistic studies in-vitro have identified a multitude of pre- and postsynaptic as well as intrinsic ionic currents through which DA modulates neural activity (reviewed in [8]).
Targeted drug development requires mode of drug action mechanistic studies in order to get approval from the FDA.
There is a need for further observational and mechanistic studies in patients with established inflammatory processes or sepsis.
Considerable advances have been made in understanding the structure and function of this family of enzymes, through high-resolution structural studies and mechanistic studies in solution.
This study highlights the importance of considering the dynamic behavior when designing resonating structures, especially when they are used for mechanistic studies in various environments.
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