Current models only partly accommodate to this trend with augmented model structures or by only analyzing subsystems leaving the following issues: (i) the lumped design of semi-mechanistic models results in a coarse mechanistic structure, which makes the integration of multiscale data and related translation steps required for fundamental research difficult.
But such formal accounts of the structures of scientific theories gloss over the mechanistic structures crucial for understanding how these theories are constructed and evaluated (Craver 2001b).
For Thompson, class was an expression of "community", not – as Marx had instructed – one component of a mechanistic structure.
In doing this, it is important to retain the mechanistic structure even for simpler models.
Again, the non-competitive Zn2+ inhibition of KLK7 agrees well with this structure based mechanistic model, in which substrate binding is still possible, as long as P2 side chains are not too large [147].
Therefore, the findings of the present thorough analysis further support such mechanistic model, which may provide a breakthrough in our understanding of the biophysical mechanism by which protein structure constrains sequence divergence.
The photosynthesis process is modeled using a precise mechanistic approach which is applicable to the commonly planted C3 species.
However, in some cases we provided a plausible mechanistic explanation, which was confirmed and supported by examples available in literature.
A mechanistic model, which explains this surface roughening behavior, is presented.
By comparing these models with existing X-ray structures of ADP-bound kinesin, we infer a mechanistic scheme in which microtubule attachment, mediated by a universally conserved 'linchpin' residue in kinesin (N255), triggers a clamshell opening of the nucleotide cleft and accompanying release of ADP.
