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Although genetic studies have alluded to an array of genes in biosynthesis of complex lipids, their mechanistic, structural, and biochemical principles have not been investigated.
NDM-1 is a "flagship" MBL which enables resistance to new generation β-lactams; Gram-negative bacteria carrying the NDM-1 gene are often referred to as "super bugs".[ 6] An enhanced mechanistic, structural and conformational understanding of NDM-1 is required for inhibitor development.
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Despite years of dedicated study, questions regarding the connections between primary and secondary metal ligands and protein structure and function remain unanswered, despite numerous mechanistic, structural, biochemical, and synthetic model studies.
Results show that in defender firms a diagnostic control use of accounting and mechanistic structural controls act as complements, while mechanistic structural controls and measure diversity act as substitutes.
While it would be impossible to survey all the details of the numerous (the count goes by thousands) species of proton-pumping rhodopsins in the framework of this review, we would like to outline the major classes of such rhodopsins and stress the interesting mechanistic and structural differences and commonalities with BR.
Despite their mechanistic and structural similarities, gyrase and topoisomerase IV have separate physiological functions.
These constructs recapitulate the aggregation behavior of htt exon 1 and have been used in biophysical, mechanistic, and structural studies by us and others.
Comparisons between Gluts (mammalian facilitative hexose transporters) and PfHT using this expression system have highlighted important mechanistic and structural differences between parasite and host proteins.
Aided by several high-throughput enzymatic assays, as well as mechanistic and structural insights, numerous potent and selective OGA inhibitors have been developed.
These studies suggest an approach for engineering plant membrane-associated P450s with enhanced expression and solubility for mechanistic and structural studies.
While the mechanistic and structural aspects of trans-translation and of tmRNA have been extensively studied, several questions remain concerning the biological role of this system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com