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The mechanistic steps, which link COX-2 overexpression with the generation of a tumour are however still not fully understood.
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Here we showed the mechanistic steps of MEFs immortalization, which share with the process of cancer development in many aspects.
This system represents an example of a most peculiar nonlinear catalytic reaction sequence for which, even though the mechanistic steps are well-accepted and their DFT energetics widely studied, the microkinetics have not yet been fully investigated.
The unsaturated end group is formed by dehydration of the chain ends by β-elimination after ester hydrolysis, which is different from the mechanistic steps of the formation of unsaturated ends in thermal decomposition of PHB.
The overall transformation occurs in a three-step sequence: (i) trans-thioesterification, (ii) S to N acyl migration, which are formally the two NCL mechanistic steps, and (iii) desulfurization of the transient thiol moiety to finally afford the ligation at the desired site.
Such desensitization apparently inhibits the catalytic action of Cdc25 on wt Ras. Figure 7 shows that two mechanistic steps are among the essential features of the process by which Cdc25 enhances the nucleotide exchange of wt Ras GTPase.
The application of structure-information approach which is "mechanism-free" makes our task simpler and thus feasible because it is not necessary to assume various mechanistic steps in order to make computations for such complicated biological property like carcinogenicity.
DRIFTS experiments corroborate some of the key mechanistic steps.
The promiscuous reactions share mechanistic steps with the normal reaction.
Similar mechanistic steps are likely followed in the catalytic dehydration of lactic acid to acrylic acid.
Furthermore, the relationship between self-aggregation mechanistic steps in water and rheological properties is reported.
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