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Thus, the results obtained here are supportive of the notion that impaired IAMs are at the mechanistic root of ASD.
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Also we observed a significant increase in the phospho-AKT levels in both the animal models upon AMPK activation indicating improved insulin sensitivity/signaling in skeletal muscle and thus support the mechanistic root for the control of fed glucose.
Detailed knowledge of such systems is crucial for our understanding of molecular phenotypes; similarly, our ability to treat and cure many diseases will depend on our understanding of molecular disease at its regulatory and mechanistic roots.
Mechanistic origin of these observations is discussed.
These rules were used to build an integrative mechanistic model of root ramification based on auxin.
We designed a mechanistic model of root ramification integrating lateral inhibition due to competition for auxin.
To test this hypothesis, we designed a mechanistic model of root ramification based on auxin fluxes (Figure 8A).
We generated a novel mechanistic model of root branching based on auxin fluxes that was able to reproduce the observed competition between primordium initiation and development.
Having established these seven principles, Coen then outlines his argument for how they lead to transformations within the common mechanistic framework of life's creative recipe: It is this recipe that lies at the root of how life transforms itself.
The strength of the work presented here is the use of foraging analogies developed elsewhere to condense a number of these complex traits into two essential mechanistic factors: root system 'growth' and 'effectiveness' (RSE).
From fruitful joint experimental and mechanistic studies rooted in the analysis of cyclic voltammograms, the mechanisms for catalysis were fully deciphered, allowing not only to give a complete picture of the catalytic processes but also to identify the main parameters for optimizing the catalyst structure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com